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Senior Medical Director, Clinical Development

Remote, MA

Posted: 02/18/2026 Employment Type: Direct Hire Job Category: Operations and Development Job Number: 4867

Job Description

As a Senior Medical Director, Clinical Development, you will be a critical leader within the R&D organization. Reporting directly to the SVP of Research & Development, you will shape clinical strategy, design and execute clinical trials, and drive development of innovative therapies.

This role requires outstanding interpersonal skills, strong learning agility, creativity, and the ability to analyze precedents — even from other therapeutic areas — to generate innovative, patient-centric solutions.
 
Essential Functions
Clinical Leadership & Strategic Planning
  • Lead clinical development activities as both an individual contributor and cross-functional leader.
  • Develop and refine the Clinical Development Plan (CDP).
  • Integrate regulatory, safety, and operational considerations.
  • Apply creative, cross-therapeutic analytical thinking.
 Study Design, Execution & Oversight
  • Lead preparation of clinical documents (protocols, SAPs, CSRs, etc.).
  • Provide medical oversight ensuring safety and data quality.
  • Analyze and interpret clinical data and present strategic implications.
  • Train internal and external teams.
 Scientific Leadership & External Engagement
  • Support scientific publications and external collaborations.
  • Participate in regulatory interactions.
  • Represent the client at scientific and strategic external meetings.
 Cross-Functional Partnership
  • Build strong relationships across R&D.
  • Use interpersonal influence to align complex stakeholder groups.
  • Promote creativity and cross-functional learning.
Key Qualifications:
  • MD or MD-PhD required.
  • 8+ years of clinical drug development experience.
  • Rare disease experience preferred.
  • Gastroenterology experience preferred but not required.
  • Academic PI experience may be considered.
 Scientific & Technical Expertise
  • Strong knowledge of clinical research methodology.
  • Ability to analyze complex clinical data.
  • Knowledge of regulatory requirements and competitive landscape.
 Leadership & Interpersonal Skills
  • Exceptional communication and influence skills.
  • Proven leadership guiding cross-functional teams.
  • Ability to build trust, navigate ambiguity, and drive alignment.
 Learning Agility & Creativity
  • Ability to learn new therapeutic areas quickly.
  • Creative problem solver.
  • Able to apply cross-therapeutic insights.
 Operational Excellence
  • Experience overseeing CROs and vendors.
  • Strong project management and execution discipline.
  • Excellent written and oral scientific communication.
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