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Scientist
Job Description
With limited supervision, plans and conducts experiments, records and analyzes data, and ensures reliable results.
Responsibilities:
Responsibilities:
- Develop and optimize bioassays to ensure successful implementation and routine execution, supporting high-throughput screening (HTS), hit characterization & assessment, lead optimization, and mechanism-of-action (MOA) studies.
- Design and conduct laboratory experiments, generate and interpret data to facilitate the development of assays and evaluate therapeutic agents.
- Learn, apply, and integrate automation solutions during assay development, MOA studies, data analysis, and reporting processes.
- Design, optimize, and implement workflows for cell line generation to enable the development of cell-based assay for screening and/or lead optimization.
- Plan and execute experiments semi-independently and adapt readily to evolving project needs.
- Identify, evaluate, and implement novel methods and techniques to develop robust bioassays, generating reliable and reproducible data efficiently.
- Stay current with the latest scientific literature and actively contribute to the interpretation of results.
- Doctorate degree OR Masters degree and 2 years of experience OR Bachelors degree and 4 years of experience
- Experience in collaborative work within a multi-disciplinary team in a biopharmaceutical environment.
- Strong scientific foundation in understanding and implementing various bioassays and readouts, including TR-FRET, BRET, Alpha, MSD, HCS, luminescence, and fluorescence.
- Expertise in the development and implementation of target engagement (TE), activity, functional, and phenotypic, and protein-protein interaction (PPI) assays to assess therapeutic agents, including thermal shift assay (TSA), probe displacement, second messenger, ion flux, reporter, protein stability, PPI (NanoBiT, NanoBRET, etc.), immunoassays, gene activation, and cellular imaging.
- Extensive experience in the functional and phenotypic characterization of engineered cells with analytical techniques, including DNA sequencing, RT-qPCR, and Western Blots.
- Experience in a variety of bioassays on more physiologically relevant cellular models such as iPSCs, 3D-culture, co-culture, and primary cells.
- Competence in setting up and operating multimode plate readers (e.g., PHERAstar, CLARIOstar, FLIPR, EnVision) and automated liquid handlers (e.g., Echo, Dragonfly, Multidrop Combi, Bravo, BioTek Plate Washer, BlueWasher) for the development of 384- and/or 1536-well microtiter plate assays.
- Familiarity with software and statistical platforms necessary for analyzing large data sets, including Screener and Spotfire.
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