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The Steely Group
http://www.thesteelygroup.com
http://www.thesteelygroup.com
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Working in collaboration with other Analytical Development team members, the Senior Research Associate will support the development and execution of late-stage assays to establish efficacy (potency), safety and product quality for AAV-based gene therapy products.
Responsibilities:
Requirements / Qualifications:
Research Associate, Analytical Development
South San Francisco, CA 94080 US
Posted: 02/19/2024
2024-02-19
2024-04-04
Employment Type:
Contract
Job Category: Scientific
Job Number: 3747
Job Description
Working in collaboration with other Analytical Development team members, the Senior Research Associate will support the development and execution of late-stage assays to establish efficacy (potency), safety and product quality for AAV-based gene therapy products.
Responsibilities:
- Develop and qualify analytical methods to measure and monitor key quality attributes for AAV therapeutic materials.
- Execute cell-based analytical test methods for infectivity and potency to support process development of AAV pipeline candidates.
- Execute molecular analytical test methods to characterize AAV genomes including qPCR
- Maintain cell lines and establish cell banks to support cell-based methods
- Qualify and pre-validate analytical test methods in preparation for method transfer to GMP CMO facilities.
- Write, prepare and present technical data, technical reports and standard operating procedures (SOPs) for internal use and transfer to external sites.
- Work within a cross-functional team to drive programs forward in a scientifically stimulating, patient-focused research environment.
Requirements / Qualifications:
- We are looking for a research associate who is independently motivated and detail-oriented, with excellent problem-solving abilities for interrogating complex molecular entities.
- BS or MS in Cell Biology, Molecular Biology, Microbiology, Biochemistry or a related discipline with at least 2 years of industry experience.
- Experience with mammalian cell culture and quantitative PCR methods required.
- Experience with viral vectors and cell-based assays is preferred.
- Experience with neuronal cell cultures is a strong plus
- Experience with plate-based and fluorescence assays is preferred
- Experience in molecular biology, protein biochemistry, biophysical characterization, and immunoassays a plus.
- Experience with kinases is a plus
- Strong communication, interpersonal, and organizational skills.
- Proven ability to work independently and effectively plan and organize work activities and prioritize task completion to meet schedules and deadlines.
- Strong collaborative work ethic and excellent time management skills for ongoing testing in parallel with new method development, in a fast-paced, scientifically rigorous, cross-functional team environment.
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