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Research Associate, Analytical Development

South San Francisco, CA 94080

Posted: 02/19/2024 Employment Type: Contract Job Category: Scientific Job Number: 3747

Job Description

Working in collaboration with other Analytical Development team members, the Senior Research Associate will support the development and execution of late-stage assays to establish efficacy (potency), safety and product quality for AAV-based gene therapy products.

  • Develop and qualify analytical methods to measure and monitor key quality attributes for AAV therapeutic materials.
  • Execute cell-based analytical test methods for infectivity and potency to support process development of AAV pipeline candidates.
  • Execute molecular analytical test methods to characterize AAV genomes including qPCR
  • Maintain cell lines and establish cell banks to support cell-based methods
  • Qualify and pre-validate analytical test methods in preparation for method transfer to GMP CMO facilities.
  • Write, prepare and present technical data, technical reports and standard operating procedures (SOPs) for internal use and transfer to external sites.
  • Work within a cross-functional team to drive programs forward in a scientifically stimulating, patient-focused research environment.
Requirements / Qualifications:
  • We are looking for a research associate who is independently motivated and detail-oriented, with excellent problem-solving abilities for interrogating complex molecular entities.
  • BS or MS in Cell Biology, Molecular Biology, Microbiology, Biochemistry or a related discipline with at least 2 years of industry experience.
  • Experience with mammalian cell culture and quantitative PCR methods required.
  • Experience with viral vectors and cell-based assays is preferred.
  • Experience with neuronal cell cultures is a strong plus
  • Experience with plate-based and fluorescence assays is preferred
  • Experience in molecular biology, protein biochemistry, biophysical characterization, and immunoassays a plus.
  • Experience with kinases is a plus
  • Strong communication, interpersonal, and organizational skills.
  • Proven ability to work independently and effectively plan and organize work activities and prioritize task completion to meet schedules and deadlines.
  • Strong collaborative work ethic and excellent time management skills for ongoing testing in parallel with new method development, in a fast-paced, scientifically rigorous, cross-functional team environment.
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