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Fermentation Scientist for Strain Engineering
Job Description
Our client is looking for an energetic and talented individual to join the multidisciplinary Protein Biochemistry group within the Research Department and drive the research activities of the strain engineering program. You will be working to understand and improve the performance of a novel prokaryotic system for biosynthesis of secreted mammalian proteins by designing and executing experiments on protein expression, mid-stream processing and analysis.
Responsibilities extend from strain evaluation using 24 or 96 well plates and pilot scale protein expression in bioreactors. In addition, the successful candidate will be required to interface with and make presentations to internal collaborators.
Responsibilities:
The ideal candidate will have the following background/skill set:
Responsibilities extend from strain evaluation using 24 or 96 well plates and pilot scale protein expression in bioreactors. In addition, the successful candidate will be required to interface with and make presentations to internal collaborators.
Responsibilities:
- Help develop company's prokaryotic protein expression platforms
- Screening of new strains for growth, protein expression and product quality in 24 or 96 well plates
- Conduct media optimization experiments to improve strain growth
- Evaluate strain performance in small-scale bioreactors through fed-batch or continuous fermentation
- Conduct mid-stream processing including harvest, cell lysis, clarification, and filtration
- Strain banking activities including Development Cell Bank production
- The candidate will also be responsible for managing fermentation supplies required for strain engineering activities
The ideal candidate will have the following background/skill set:
- Ph.D. in Biochemistry, Chemical Engineering, or a related discipline with 2 years post-Ph.D. experience preferred.
- Minimum of 3 years of hands-on experience working with small-scale bioreactors is required
- Experience working with in vivo protein expression required. Experience working with antibodies or antibody fragments preferred
- Proficiency with common protein analytical techniques including SDS-PAGE and Western blotting
- Familiarity with statistical analysis software for design of experiments, such as JMP, and sequence analysis software, such as SnapGene is preferred
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