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Senior/Principal Scientist, Computational Chemistry

Cambridge, MA

Posted: 05/21/2020 Employment Type: Direct Hire Job Category: Clinical: Scientific Job Number: 2567

Job Description


Our client is looking for a results oriented, strategic thinker to apply computational chemistry, structural bioinformatics, cheminformatics, and medicinal chemistry design principles to support its drug discovery programs and target identification/validation efforts.

Responsibilities include:
  • Structure and ligand based compound design, virtual screening, and library design
  • Structural bioinformatics to evaluate target class similarity and support target and lead hopping based design of compounds
  • Chemical tractability assessment techniques
  • Prediction of compound physicochemical and ADME properties to aid in compound design and selection
  • Cheminformatics techniques for HTS analysis, library design, SAR visualization, and target selection
  • Development and application of novel computational capabilities, e.g., FEP, protein simulations, and analysis

Requirements/Qualifications:  
  • A passion for discovering new medicines to treat serious disease
  • A PhD and 5+ years of computational chemistry experience within a pharmaceutical or biotechnology setting is required
  • Proficiency in all aspects of modern computational chemistry
  • Demonstrated impact in applying computational chemistry to drive the design and progression of compounds in a drug discovery team setting as evidenced by publications and patent applications
  • Experience in working as a member of drug discovery teams in early through to late stage discovery
  • Deep understanding of medicinal chemistry, DMPK principles, multi-parameter compound design and optimization
  • Strong interpersonal and communication skills

Meet Your Recruiter

Tracey Goldthwaite
Senior Vice President

Tracey spearheads the firm’s Commercial practice and focuses on identifying and placing individuals in leadership roles within Global Marketing, Medical Affairs, New Product Planning, and Patient Advocacy and Engagement, to name a few. With 25 years of experience, she also plays a key role in the Clinical Staffing practice, recruiting top talent of all levels for positions in our core areas including Clinical Operations and Development, Regulatory Affairs, Pharmacovigilance and Program Management.

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