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Scientist - Translational Sciences (Hematology/Oncology)

Cambridge, MA

Posted: 08/07/2019 Employment Type: Direct Hire Job Category: Clinical: Scientific Job Number: 2319

Our client seeks a motivated scientist to conduct research to support the advancement of portfolio small molecule inhibitors into clinical trials in targeted cancer indications and patient populations. The incumbent will identify predictive biomarkers for enrichment of patient populations most likely to respond to their agents in the clinic, and pharmacodynamic biomarkers to monitor target engagement.  The position requires expertise in cancer biology and/or chromatin biology, and a passion to contribute to high quality scientific research to drive programs into the clinic. We are seeking a highly motivated, independent, and skilled candidate who will be responsible for planning, execution, interpretation and presentation of data to drive translational programs.

Primary Responsibilities:
  • Key contributor to translational science programs, and delivery of scientific discoveries impacting decision-making at team meetings
  • Design and perform complex chromatin-focused experiments to support hypotheses around the biological functions and molecular mechanisms of oncology targets
  • Identification/validation of biological contexts that create a dependency on a given drug target to aid indication/context prioritization for clinical development. This entails both performing and guiding internal efforts, as well as external efforts with CROs or collaborators.
  • Closely work with bioinformatics group to use genomic, epigenomic, and/or transcriptomic data to generate novel biomarker hypotheses and identify novel biomarkers
  • Identification and clinical translation of biomarker assays that assess drug pharmacodynamics, and allow testing of preclinical response hypotheses enabling differentiating path for small molecular inhibitor development
  • Be part of a highly skilled translational team that shares a common goal of delivering optimal path forward for clinical development.

Requirements/Qualifications:
  • Ph.D. in molecular or cellular biological sciences with emphasis on cancer biology, and  a minimum of 3 years of industry experience
  • Broad knowledge and laboratory research experience in oncology and/or epigenetics space as demonstrated by peer-reviewed publications
  • Experience working with CROs for clinical assay development, implementation and execution
  • Detail-oriented, self-motivated, and ability to work independently
  • Strong oral and written communication skills, writing reports and giving updates at team meetings is required. The ability and desire to work in a challenging dynamic environment under tight deadlines is required

Lisa Madden
EVP, Clinical Staffing

Lisa is an inspiring leader and mentor, driven by an inherent desire to help others and make a difference. An advocate for growth and professional development, Lisa brings 18 years of recruiting and business development experience to The Steely Group, and as Executive Vice President of Clinical Staffing, she oversees the direction and strategy of the Steely recruiting team.

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