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Head of Discovery Biology

Cambridge, MA

Posted: 06/13/2019 Employment Type: Direct Hire Job Category: Clinical: Scientific Job Number: 2354

As the head of our Client’ s discovery biology organization championing new targets for portfolio entry and supporting portfolio candidate targets through various drug discovery stages, you will have an immediate impact on defining their current and future portfolio. You will lead a team responsible for the discovery and validation of the next wave of targets, execution of cell-based and in vivo assays to support the pipeline programs, bioinformatics and bench efforts to elucidate the molecular consequences of target inhibition and work together with the drug discovery and translational teams to advance compelling pipeline assets. You will work closely with other key stakeholders in Research and Clinical to identify and advance novel targets for the company. You will independently lead a group of bench scientists and the functional genomics department and oversee the management of work with external vendors and academic laboratories.

Key Responsibilities:
  • Enabling and guiding target discovery efforts from a disease biology perspective by overseeing all target identification and target credentialing efforts
  • Leading and mentoring growing teams of scientists working on pre-portfolio target opportunities and in-portfolio drug discovery programs at various stages
  • Collaborating with the translational and clinical teams to generate and prioritize novel oncology target opportunities and compelling oncology development paths
  • Selecting vendors and academic laboratories for in vitro and in vivo assay implementation and execution; coordinate/manage their work flow and budgets and ensure timely delivery of data
  • Contributing to the overall research strategy, including prioritization of targets to be evaluated, determination of appropriate cell based assays to support drug discovery campaigns, and devise animal studies that support the disease rationale for candidate targets.
  • Spend your day in a team-oriented mode of operation and collaborative work with peers in discovery biology, functional genomics and cross functional drug discovery project teams

Requirements / Qualifications:
  • Ph.D., or equivalent degree is required
  • At least 15 years relevant experience with a minimum of 10 years in industry
  • Experience with utilizing cancer genomic information as a guiding principle for target selection and prioritization and for development of biomarker strategies is required
  • Firsthand knowledge of oncology target discovery and what it takes to advance a preclinical portfolio and how to increase the probability of success to deliver product candidates for development
  • Firsthand experience guiding the biology efforts of small molecule H2L and LO drug discovery programs, including at least one each, early and late stage small molecule discovery programs
  • Successful years immersed in the oncology space
  • Ability to work with anyone, in any functional area
  • Added intellectual, innovated value showcased by your publication record and novel thinking on prior clinical programs.
  • Excellent communication and interpersonal skills
  • Working knowledge of genetic / genomic and / bioinformatic technologies in order to guide their application in target discovery approaches, especially in oncology
  • Immunology background or preclinical experience with immune checkpoint inhibitors beneficial

Tracey Goldthwaite
Senior Vice President

Tracey has more than 20 years experience in the staffing and recruiting industry. She spearheads The Steely Group's Client Services efforts, ensuring superior customer service, communication, and ongoing support to clients and candidates alike. Additional areas of expertise include client relationship management and team building.
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