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DMPK Modeling and Simulation Scientist (Sr. Investigator)

Cambridge, MA

Posted: 08/24/2020 Employment Type: Direct Hire Job Category: Clinical: Scientific Job Number: 2642

Job Description


Our client is looking to add a Modeling and Simulation Scientist to their team on a permanent basis who will be primarily responsible to deliver a quantitative and mechanistic understanding of PK/PD/efficacy relationships to support project teams from early discovery through early clinical development.

In addition, this individual will be involved in the design, execution, analysis, interpretation and communication of pharmacokinetics (PK) and absorption, distribution, metabolism, and excretion (ADME) studies of to support drug development from early discovery through preclinical and clinical development. The individual will serve as DMPK project representative to coordinate and lead all nonclinical DMPK activities on programs from the research phase through development. An individual with in-depth knowledge and expertise in PK/PD modeling and simulation and ADME would be essential.

Principal Duties and Responsibilities:
  • Deliver a quantitative and mechanistic understanding of PK/PD/efficacy relationships to support drug discovery and development teams
  • Design and execute preclinical studies to understand the pharmacokinetics (PK) and absorption, metabolism, distribution, and excretion (ADME) of drug candidates
  • Represent DMPK as the subject matter expert to project teams, develop and drive DMPK and PK/PD strategy for Drug Discovery projects
  • Responsible for the analysis, interpretation, integration and reporting of preclinical DMPK data generated both internally and with external vendors
  • Participate in the management of CROs in the conduct of in vitro/in vivo ADME studies
  • Partner with and support Drug Safety, Research, Clinical, Regulatory, Project Management and other departments

Qualifications:
  • PhD. in Pharmacokinetics, Pharmacology, Pharmaceutics or other relevant field with 5 years of experience in the biopharmaceutical industry, with evidence of modeling and simulation experience
  • Conceptual fluency with modeling, and in depth hands-on modeling experience (e.g. using WinNonlin Phoenix, MATLAB/Simbiology, PK Sim, Simcyp, or NONMEM to develop PK/PD models)
  • Strong knowledge of drug metabolism, ADME concepts, pharmacokinetics, pharmacodynamic and bioanalytical principles is required.
  • Experience with biologics desirable but not required.
  • Strong communication (verbal and written) and presentation skills required
  • Excellent interpersonal skills and ability to represent DMPK in a team environment are essential

Meet Your Recruiter

Lisa Madden
EVP, Clinical Staffing

Lisa is an inspiring leader and mentor, driven by an inherent desire to help others and make a difference. An advocate for growth and professional development, Lisa brings 18 years of recruiting and business development experience to The Steely Group, and as Executive Vice President of Clinical Staffing, she oversees the direction and strategy of the Steely recruiting team.

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