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Research Associate

Cambridge, MA 02138

Posted: 07/17/2024 Employment Type: Contract Job Category: Scientific Job Number: 3846

Job Description

This position offers the opportunity to impact a growing portfolio of targeted therapies in a fast-paced and innovative research environment.

Our client is searching for a dynamic Associate Biology Scientist with experience interrogating cellular and molecular mechanisms as they relate to kinase target pathway modulation, off-target liabilities, and resistance.  
  • Independently, develop, optimize, and proactively troubleshoot cellular screening assays. 
  • Responsible for generating, processing, interpreting, and presenting data in cross functional team meetings 
  • Proactively employ cell and molecular biology techniques, including gene targeting approaches and small molecule inhibition, to dissect mechanism of action. 
  • Independently design, execute and document experiments to evaluate target dependency, off target liabilities, phenotypic responses and identifying resistance mechanisms. 
  • Regularly share and present data with team members. 

Requirements / Qualifications:  
  • MS/BS in oncology, cellular biology, molecular biology, or related discipline with 1+ years of industry or relevant research experience is required.  
  •  Experience in developing and optimizing cell-based assays in multiple platforms (for example CTG, HTRF, AlphaLISA, FC, Jess-WB, NanoBret, Nanostring). 
  • Experience with different molecular and cellular biology techniques (such as Western Blot). 
  • Experience with genome editing (CRISPR or si/shRNA) for engineering cell line models is a plus. 
  • Familiar with tumor models and establishing PK/PD/efficacy relationships and delivering PD readouts by western blots for in vivo tumor models. 
  • Experience with standard software analytical tools, xlsx, Prism, or other synergy software. 
  • Strong oral and written communication skills, as well as excellent documentation and organizational skills. 
  • A team player, who listens effectively, invites response and discussion. 
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